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It works differently than PEA+ALC, so it could potentially produce synergistic effects

However, its receptor residence time the duration the ligand remains bound is relatively short, on the order of 36 minutes, in contrast to salmon calcitonins residence time of approximately 4560 minutes

Additionally, it slows digestion, stabilizing blood sugar levels and improving overall metabolic health

The authors suggest that either methyl-B12 and adenosyl-B12 should be given together, or either cyano-B12 or hydroxo-B12 on their own, both of which can be converted into both active forms

The ideal B12 supplement contains a mix of methylcobalamin, hydroxocobalamin and adenosylcobalamin (11)